/Chronic kidney disease stage 4 with proteinuria

Chronic kidney disease stage 4 with proteinuria

author:admin       pubdate:2017-08-10 11:43

How should be nephrosis long-term albuminuria treated, today we will discuss this problem

First: because the reabsorption of glomerular membrane filtration and renal tubules, protein in the urine of healthy people (especially low molecular weight protein) content was little (daily output is less than 150 mg), qualitative examination of protein, showed a negative reaction. When the increase of protein content in urine, normal urine routine examination can be measured, called proteinuria. If the urine protein content of more than 3.5g/24h, is known as proteinuria.

A large number of protein from the urine loss, the patient has any harm?

A large number of proteinuria results in massive loss of plasma proteins and causes hypoproteinemia. The following effects are also present:

An increase in hyperlipidemia hyperlipidemia and low protein expression is positively related to the blood viscosity, promote thrombosis, embolism complications, will also increase the cardiovascular complications, and may promote glomerular sclerosis and renal tubular Jianzhi lesions, chronic kidney disease and promote development.

Two, immune globulin decrease caused by the low immunity to infection;

Three, the loss of metal binding proteins can lead to the lack of trace elements;

Four, the reduction of drug binding proteins may affect the pharmacokinetics of certain drugs and affect the efficacy of drugs;

Five, endocrine protein deficiency can induce endocrine disorders;

Finally, a small nephrotic syndrome in children usually results in a large amount of proteinuria, mainly due to impairment of the glomerular membrane charge barrier

Long term hypoproteinemia can lead to malnutrition and affect the growth and development of children

Second: proteinuria is the typical symptoms of chronic nephropathy, proteinuria and glomerular barrier formation has a close relationship. The glomerular capillary is composed of three layers, from inside to outside were endothelial cells layer, basal layer and epithelial cell layer. Because the three layer cells are distributed with filter holes of varying sizes and a negative charge, so the glomerular capillary barrier function can be pided into two types, namely mechanical barrier - filter hole and charge barrier -- negative charge.

Third: no obvious edema and hypertension without limiting water and sodium intake, increasing water is very important to increase the amount of urine. Mild to moderate azotemia patients do not limit protein intake to maintain body nitrogen balance, especially the daily loss of protein quality more and more attention should be paid to the patients with heavy proteinuria. Mild azotemia can increase the vegetable protein, such as soybeans and other severe azotemia, or in the near future of azotemia appropriate limit protein intake.

Most of the people who appear on albuminuria attitude is panic, but now medical care at a loss, has made considerable development, including the treatment of proteinuria have significantly improved. So if you unfortunately suffer from the disease, must not panic, with medical treatment make a speedy recovery.


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