Renal osteodystrophy can be pided into generalized renal osteodystrophy and narrow renal osteodystrophy in two categories: generalized "renal osteodystrophy" refers to all related bone disease and kidney or cause kidney related bone disease, such as renal tubular acidosis associated with rickets, nephrotic syndrome occurs when bone; narrow sense "renal osteodystrophy" also known as renal osteodystrophy, refers to chronic renal failure (CRF) of metabolic bone disease, can be regarded as an important complication of CRF, severe cases may be associated with multiple system lesions.
Classification of renal osteopathy
According to the rate of bone turnover, renal osteopathy can be pided into 4 types
1, high transformation type bone disease
According to the pathological osteitis fibrosa, hyperparathyroidism, osteoblast, osteoclast proliferation characteristics around the active and trabecular fibrosis.
2, low conversion bone disease
Including bone softening and non dynamic osteopathy two. The former refers to the formation of the new class of defective bone mineralization, usually caused by the precipitation of aluminum. The latter was associated with reduced bone formation, hypercalcemia and diabetes and other factors.
3, mixed osteopathy
At the same time, it has the characteristics of high transformation and low transformation bone disease. It is caused by hyperparathyroidism and bone mineralization disorder, characterized by increased bone formation and coexistence of medullary fibrosis, and the rate of bone turnover varies
4, beta 2-, amyloid, amyloidosis, osteoarthritis
How is renal osteopathy treated?
We should pay attention to adjust the diet structure, such as the increase of high calcium low phosphorus foods. Followed by drug treatment, if low blood calcium, generally taking calcium carbonate and ossification in three alcohol; if the blood phosphorus is high, the general use of calcium based phosphate binders containing calcium or parathyroid hormone; if high, usually taking vitamin D this kind of activity drugs. Some drugs can be used together.
The drug has some side effects, such as calcium carbonate, easily lead to constipation and gastrointestinal discomfort, may also cause the blood calcium level increased and aggravate vascular calcification; in addition to active vitamin D also has this risk. So during the treatment requires frequent monitoring of serum calcium, phosphorus and other indicators; if the blood calcium, blood phosphorus increased, then this the medicine can not be used, the need for other drugs.
Early application of positive drug treatment effect is very good, but some patients often ignore early treatment. Wait until the appearance of skeletal deformity, pain, skin itching and other serious symptoms, patients have reached an advanced stage; it has missed the drug treatment time, this kind of situation and effect of drug treatment is not good, maybe only surgery.
Renal osteodystrophy is slow, symptoms are advanced, clinically with bone pain, bone fracture, deformation is the main feature. One of the sudden pain symptoms, often systemic, occur in the lower part of the body parts (discreet waist, back, hip, knee, or compression movement) and heavy walking shake even can't get up. Pathological fracture of multiple ribs, other parts can also be due to a slight force caused by fracture of adult prone vertebrae, thoracic and pelvic deformation caused by height and ventilation in patients with severe disorders, known as the shrinking man syndrome can occur in children, growth delay.