Why renal biopsy is necessary for nephrotic syndrome? Renal biopsy is the major cause of nephrotic syndrome. Nephrotic syndrome is not a disease, it’s a group of diseases with similar clinical features. The use of renal biopsy is conducive to clear diagnosis, guiding treatment, prognosis, and explore the relationship between clinical classification and pathological typing, and is also the main method to improve the level of clinical treatment of kidney disease.
Definite diagnosis: there are basically 2 kinds of diagnostic methods for renal disease at present. One is clinical diagnosis, the other two is immune pathological diagnosis. The combination of the two can make a definite diagnosis and therefore must rely on renal biopsy. For example, clinically manifested as nephrotic syndrome, the pathology can be found in many pathological types, such as small lesions, podocyte disease, IgA nephropathy, membranous nephropathy, focal segmental glomerulosclerosis, and final diagnosis must rely on pathological diagnosis. And other rare diseases, such as amyloidosis, lipoprotein nephropathy, and other clinical manifestations of nephrotic syndrome, such as biopsy, clinical diagnosis.
Guiding treatment: after renal biopsy, the diagnosis can be made for the clinical treatment plan and the correction of the treatment program. If the renal biopsy in the diagnosis of small lesions, application of hormone therapy has good effect, and other pathological types, response to hormone therapy is different, may use cytotoxic drugs early, so as not to delay the disease.
Prognosis: after renal biopsy, the prognosis of the disease can be basically estimated. The clinical diagnosis of the same type of nephropathy is different, and the prognosis is not the same.