Causes of nephrotic syndrome appear hyperlipidemia

Blood lipids mainly include cholesterol, triglycerides and phospholipids. Blood lipids are conjugated to proteins in plasma and form and transport in the form of lipoproteins. Lipoproteins have five classes, namely, Chylous (CM), low-density lipoprotein (LVDL), low-density lipoprotein (LDL), medium density lipoprotein (1DL), and high-density lipoprotein (HDL). 

The mechanism of hyperlipidemia in nephrotic syndrome is still remains unclear, at preasent think nephrotic syndrome, hypoproteinemia caused by the colloid osmotic pressure decreased and (or) in the urine a loss caused by increased synthesis of regulatory factors on liver cholesterol, triglyceride and lipoprotein. In addition, lipoprotein lipase activity decreases in nephrotic syndrome resulting in lipid clearance. At the same time, in experimental nephrotic syndrome, hemolysis, lipid acyltransferase activity increased, this enzyme can catalyze the lecithin acetylation into lecithin, so that blood phospholipids increased. This leads to hyperlipidemia in nephrotic syndrome.

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